The Mouse anti Integrin beta 1D Antibody from MyBioSource.com is a Mouse Monoclonal antibody to CD29, GPIIA', integrin beta 1, integrin, beta 1a, and ITGB1. This antibody recognizes Human, Mouse, Canine, and Porcine antigen. The Mouse anti Integrin beta 1D Antibody has been validated for the following applications: Immunocytochemistry, Immunohistochemistry, Immunohistochemistry - frozen, and Western Blot.
Description
Integrins are a family of heterodimeric membrane glycoproteins consisting of non-covalently associated alpha and beta subunits. More than 18 alpha and 8 beta subunits with numerous splice variant isoforms have been identified in mammals. In general, integrins function as receptors for extracellular matrix proteins. Certain integrins can also bind to soluble ligands or to counter-receptors on adjacent cells, such as the intracellular adhesion molecules (ICAMs), resulting in aggregation of cells. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migRation and apoptosis. There are two major forms of integrin beta1: beta1A and beta1D, which differ in 13 amino acids. Their distribution pattern in adult tissues is mutually exclusive. beta1A is present in all tissues, except cardiac and skeletal muscle, which instead express the beta1D variant